2. Signaling Pathways
  3. PROTAC
  4. E3 Ligase Ligand-Linker Conjugates

E3 Ligase Ligand-Linker Conjugates

E3 Ligase Ligand-Linker Conjugates

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E3 Ligase Ligand-Linker Conjugate, which is one part of Proteolysis Targeting Chimeric Molecules (PROTACs), incorporates a ligand for the E3 ubiquitin ligase and a linker. After linked to the ligand for target protein (such as JQ1 for BRD4 protein, Molibresib for BET protein), those conjugates can be used for constituting PROTACs that targetprotein for ubiquitination and degradation. Currently, several PROTACs have been found to show good biological activity by specifically targeting BET, estrogen receptor (ER), androgen receptor, etc. MedChemExpress (MCE) offers a wide range of high quality E3 Ligase Ligand-Linker Conjugates including von Hippel-Lindau (VHL) ligands, MDM2 ligands, Cereblon (CRBN) ligands and cIAP1 ligands conjugating with different linkers (PEGs, Alkyl-Chain, Alkyl/ether, etc.). It’s convenient and time-saving for designing and synthesizinga wide variety of novel PROTACs (ARV-825, dBET1,MT-802, etc.), which can expand the application of PROTACs in the treatment of cancer, autoimmunity, inflammation and other diseases.

E3 Ligase Ligand-Linker Conjugates Isoform Specific Products:

E3 Ligase Ligand-Linker Conjugates Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-148142
    Pomalidomide-C3-NHS ester 2828476-87-3 98.70%
    Pomalidomide-C3-NHS ester is a synthesized E3 ligase ligand-linker conjugate, incorporating the Pomalidomide based cereblon ligand and NHS ester linker.
    Pomalidomide-C3-NHS ester
  • HY-130716
    Thalidomide-NH-C10-COOH 2428400-33-1
    Thalidomide-NH-C10-COOH (compound 6b) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based CRBN ligand and a linker used in PROTAC technology.
    Thalidomide-NH-C10-COOH
  • HY-161128
    Lenalidomide 4'-PEG1-amine dihydrochloride 2624336-86-1 98.42%
    Lenalidomide 4'-PEG1-amine dihydrochloride is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide 4'-PEG1-amine dihydrochloride can be connected to the ligand for protein by a linker to form PROTAC.
    Lenalidomide 4'-PEG1-amine dihydrochloride
  • HY-140844
    Thalidomide-O-PEG4-azide 2380318-57-8 98.02%
    Thalidomide-O-PEG4-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Thalidomide-O-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Thalidomide-O-PEG4-azide
  • HY-138848A
    Thalidomide-4-O-C5-NH2 hydrochloride 2419145-66-5
    Thalidomide-4-O-C5-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
    Thalidomide-4-O-C5-NH2 hydrochloride
  • HY-130713
    Thalidomide-C2-amido-C2-COOH 2353496-84-9 98.45%
    Thalidomide-C2-amido-C2-COOH incorporates a CRBN ligand for the E3 ubiquitin ligase, and a linker. Thalidomide-C2-amido-C2-COOH can be used to design PROTAC CDK2/9 Degrader-1 (HY-130709).
    Thalidomide-C2-amido-C2-COOH
  • HY-115446A
    Lenalidomide-C4-NH2 hydrochloride 2435715-90-3
    Lenalidomide-C4-NH2 hydrochloride is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C4-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTAC (Compound 24), which has IC50s of 0.98 nM and 13.7 nM in inhibition of RS4;11 and MOLM-13 acute leukemia cell lines growth, respectively.
    Lenalidomide-C4-NH2 hydrochloride
  • HY-155262
    Pomalidomide-5-C6-NH2 hydrochloride 3007650-02-1 98.46%
    Pomalidomide-5-C6-NH2 hydrochloride is the Pomalidomide (HY-10984)-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide-5-C6-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTAC.
    Pomalidomide-5-C6-NH2 hydrochloride
  • HY-160241
    Lenalidomide-C5-acid 2338824-30-7
    Lenalidomide-C5-acid is the Lenalidomide-based E3 ligase ligand-linker conjugate used in the recruitment of CRBN protein. Lenalidomide-C5-acid can be used to synthesize PROTACs.
    Lenalidomide-C5-acid
  • HY-103612
    Thalidomide-O-amido-C3-COOH 2308035-51-8 98.43%
    Thalidomide-O-amido-C3-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
    Thalidomide-O-amido-C3-COOH
  • HY-135045
    (S,R,S)-AHPC-C4-COOH 2172819-74-6
    (S,R,S)-AHPC-C4-COOH (VH032-C4-COOH) (linker 45) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used for EED-targeted PROTAC.
    (S,R,S)-AHPC-C4-COOH
  • HY-129608
    Lenalidomide-acetylene-C5-COOH 2429878-72-6 99.26%
    Lenalidomide-acetylene-C5-COOH (compound 43; Cereblon ligand-linker Conjugate) is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-acetylene-C5-COOH can be connected to the ligand for protein by a linker to form PROTAC. Lenalidomide-acetylene-C5-COOH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Lenalidomide-acetylene-C5-COOH
  • HY-136184
    (S,R,S)-AHPC-phenol-C4-NH2 dihydrochloride 2376990-26-8 99.01%
    (S,R,S)-AHPC-phenol-C4-NH2 (VH032-phenol-C4-NH2) dihydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used in PROTAC technology.
    (S,R,S)-AHPC-phenol-C4-NH2 dihydrochloride
  • HY-136163
    (S,R,S)-AHPC-C2-NH2 dihydrochloride 2341796-73-2 98.63%
    (S,R,S)-AHPC-C2-NH2 dihydrochloride incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. (S,R,S)-AHPC-OH can be used in the synthesis of a series of PROTACs.
    (S,R,S)-AHPC-C2-NH2 dihydrochloride
  • HY-114176B
    (S,R,S)-AHPC-C4-NH2 dihydrochloride 2341796-78-7
    (S,R,S)-AHPC-C4-NH2 dihydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used for EED-Targeted PROTAC.
    (S,R,S)-AHPC-C4-NH2 dihydrochloride
  • HY-107438A
    Thalidomide-O-amido-C4-NH2 hydrochloride 2245697-86-1 98.11%
    Thalidomide-O-amido-C4-NH2 hydrochloride, a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs.
    Thalidomide-O-amido-C4-NH2 hydrochloride
  • HY-136183
    (S,R,S)-AHPC-phenol-alkylC6-amine dihydrochloride 2376990-28-0 98.16%
    (S,R,S)-AHPC-phenol-alkylC6-amine dihydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and an alkyl linker used for PROTAC degrader.
    (S,R,S)-AHPC-phenol-alkylC6-amine dihydrochloride
  • HY-134982
    Thalidomide-piperazine-Boc 2222114-64-7 98.82%
    Thalidomide-piperazine-Boc is an intermediate that can be used in the synthesis of B-cell lymphoma 6 protein (BCL6) PROTAC.
    Thalidomide-piperazine-Boc
  • HY-138772
    Thalidomide-NH-PEG2-COOH 2412056-45-0 98.65%
    Thalidomide-NH-PEG2-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
    Thalidomide-NH-PEG2-COOH
  • HY-130521
    Pomalidomide-amido-PEG3-C2-NH2 2328070-52-4 99.55%
    Pomalidomide-amido-PEG3-C2-NH2 (Cereblon Ligand-Linker Conjugates 22) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology.
    Pomalidomide-amido-PEG3-C2-NH2
Cat. No. Product Name / Synonyms Application Reactivity
E3 Ligase Ligand-Linker Conjugates Isoform Comparison

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